Few large backpacks on the market are lightweight, feature durable materials, and haul a lot of gear comfortably. The Tenba Axis V2 32L manages to check each of those items. It can carry multiple camera systems, lenses, a tripod, a water bottle, and a 17" laptop with room to spare
I’ve used the Lowepro Flipside backpacks almost religiously. The Flipside design allows photographers to swing the bag forward on the waist belt, open up the full back panel, grab anything out of the main compartment, flip the bag back, and keep shooting.
Everyone else can pack it up and go home now because you're probably not going to beat what Tenba has done this year. Tenba refreshed the DNA messenger bag lineup and made minor improvements. But what's been improved are some of the biggest things for usability.